Image: Neural basis of opioid-induced respiratory depression and its rescue
Shijia Liu et al.
Cellular
Identifying the functions of two biomarkers in human oligodendrocyte progenitor cell development
Haipeng Zhou, Ying He, Yinxiang Yang, Zhaoyan Wang, Qian Wang, Caiyan Hu, Xiaohua Wang, Siliang Lu, Ke Li, Zuo Luan
Depletion of senescent cells improves functional recovery after spinal cord injury
Diogo Paramos-de-Carvalho, Isaura Martins, Ana Margarida Cristovao, Ana Filipa Dias, Dalila Neves-Silva, Telmo Pereira, Diana Chapela, Ana Farinho, Antonio Jacinto, Leonor Saude
Midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms
Ingrid Ehrlich, Ayla Aksoy-Aksel, Andrea Gall, Anna Seewald, Francesco Ferraguti
Gene expression
Reelin haploinsufficiency affects skilled motor performance associated with suppression of training-induced gene enrichment, synaptic function and activity-dependent cortical plasticity in mice.
Mariko Nishibe, Yu Katsuyama, Hiroki Toyoda
KCC2 is required for the survival of mature neurons but not for their developmentGeorgina Kontou, Josephine Ng, Ross Andrew Cardarelli, Jack Howden, Catherine Choi, Qiu Ren, Josef Kittler, Nicholas Brandon, Stephen J. Moss, Joshua L. Smalley
The effects of CSTB duplication on APP/amyloid-β pathology and cathepsin activity in a mouse model
Yixing Wu, Heather T. Whittaker, Suzanna Noy, Karen Cleverley, Veronique Brault, Yann Herault, Elizabeth M. C. Fisher, Frances K. Wiseman
Molecular
Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs
Priyanka Patel, Courtney Buchanan, Amar N Kar, Seung Joon Lee, Anatoly Urisman, Pabitra K Sahoo, Juan A Oses-Prieto, Michalea Dell Orco, Devon E Cassiday, Sharmina Miller, Elizabeth Thames, Terika P Smith, Matthew D Zdradzinski, Alma Burlingame, Nora Perrone-Bizzozero, Jeffery L Twiss
PKD promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons (R)
Carlos Omar Oueslati Morales, Attila Ignacz, Norbert Bencsik, Aniko Erika Ratkai, Wolfgang Sebastian Lieb, Stephan A. Eisler, Attila Szucs, Katalin Schlett, Angelika Hausser
Graded calcium spikes differentially signal neurotransmitter input in cerebrospinal fluid contacting neurons of mouse spinal cord (R)
Emily Johnson, Marilyn Clark, Claudia MacLean, James Deuchars, Susan A Deuchars, Jamie Johnston
Medial septum neurokinin- and somatostatin-sensitive mechanisms mediate sensorimotor and nociceptive behaviours
Si Yun Ng, Andy Thiam-Huat Lee, Mohammed Zacky Ariffin, Pei Jun Woon, Terence Sheng Hao Chng, Sanjay Khanna
Metaplastic reinforcement of long-term potentiation in rat hippocampal area CA2 by cholinergic receptor activation
Amrita Benoy, Mohammad Zaki Bin Ibrahim, Thomas Behnisch, Sajikumar Sreedharan
The role of parvalbumin interneuron GIRK signaling in regulation of affect and cognition in male and female mice
Eden Anderson, Skyler Demis, Hunter D’Acquisto, Annabel Engelhardt, Matthew Hearing
Phosphorylation triggers presynaptic phase separation of Liprin-α3 to control active zone structure
Javier Emperador Melero, Man Yan Wong, Shan Shan H Wang, Giovanni De Nola, Tom Kirchhausen, Pascal S Kaeser
Epitomic analysis of the specificity of conformation-dependent, anti-aβ amyloid monoclonal antibodies (R)
Jorge Mauricio Reyes-Ruiz, Rie Nakajima, Ibtisam Baghallab, Luki Goldschmidt, Jutyna Sosna, Phuong Nguyen Mai Ho, Taha Kumosani, Philip L Felgner, Charles G Glabe
Endothelial iron homeostasis regulates BBB integrity via the HIF2α-Ve-cadherin pathway
Daniel Rand, Orly Ravid, Dana Atrakchi, Hila Israelov, Yael Bresler, Chen Shemesh, Liora Omesi, Sigal Liraz-Zaltsman, Fabien Gosselet, Tabor Maskrey, Michal Schnaider Beeri, Peter Wipf, Itzik Cooper
Oleic acid triggers hippocampal neurogenesis by binding to TLX/NR2E1
Prasanna Kandel, Fatih Semerci, Aleksandar Bajic, Dodge Baluya, Lihua Ma, Kevin Chen, Austin Cao, Tipwarin Phongmekhin, Nick Matinyan, William Choi, Alba Jimenez-Panizo, Srinivas Chamakuri, Idris O. Raji, Lyra Chang, Kevin R MacKenzie, Pablo Fuentes-Prior, Eva Estebanez-Perpina, Caroline L. Benn, David D Moore, Koen Venken, Damian W Young, Mirjana Maletic-Savatic
Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells
Michael D Flood, Erika D Eggers
Ethanol’s action at BK channels accelerates the transition from moderate to excessive alcohol consumption
Agbonlahor Okhuarobo, Max Kreifeldt, Pushpita Bhattacharyya, Alex M Dopico, Amanda J Roberts, Gregg E Homanics, Candice Contet
Differential Effects of Propofol and Ketamine on Critical Brain Dynamics (R)
Thomas F Varley, Olaf Sporns, Aina Puce, John Beggs
Topological Analysis of Differential Effects of Ketamine and Propofol Anesthesia on Brain Dynamics (R)
Thomas F. Varley, Vanessa Denny, Olaf Sporns, Alice Patania
Pathophysiology
Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson’s disease
Arun Singh, Rachel Cole, Arturo I. Espinoza, Aron Evans, Scarlett Cao, James F. Cavanagh, Nandakumar S. Narayanan
Altered neural oscillations and behavior in a genetic mouse model of NMDA receptor hypofunction
David D Aguilar, Leana K Radzik, Felipe L Schiffino, Oluwarotimi Folorunso, Mark R Zielinski, Joseph T Coyle, Darrick T Balu, James M McNally
Brunner syndrome associated MAOA dysfunction in human dopaminergic neurons results in NMDAR hyperfunction and increased network activity.
Yan Shi, Jon-Ruben van Rhijn, Maren Bormann, Britt Mossink, Monica Frega, Hatice Recaioglu, Marina Hakobjan, Teun M Klein Gunnewiek, Chantal Schoenmaker, Elizabeth Palmer, Laurence Faivre, Sarah Kittel-Schneider, Dirk Schubert, Han Brunner, Barbara Franke, Nael Nadif Kasri
Neural basis of opioid-induced respiratory depression and its rescue
Shijia Liu, Dong-Il Kim, Tae Gyu Oh, Gerald M Pao, Jong Hyun Kim, Richard D Palmiter, Matthew M Banghart, Kuo-Fen Lee, Ronald M Evans, Sung Han
Increased orbitofrontal connectivity in misophonia
Leonardo Cerliani, Romke Rouw
Amyloid β Impacts Future Freezing of Gait in Parkinson’s Disease Via White Matter Hyperintensities (R)
Mahsa Dadar, Janis Miyasaki, Simon Duchesne, Richard Camicioli
Protein kinase CK2 alpha prime and alpha-synuclein constitute a key regulatory pathway in Huntington′s disease
Dahyun Yu, Nicole Zarate, Francesco Cuccu, Johnny S Yue, Taylor G Brown, Wei Tsai, Rachel Mansky, Kevin Jiang, Hyuck Kim, Carmen Nanclares, Tessa Nichols-Meade, Sarah N Larson, Katie Gundry, Ying Zhang, Michael Benneyworth, Gülin Öz, Marija Cvetanovic, Alfonso Araque, Rocio Gomez-Pastor
Structural and functional
Overlapping and unique neural circuits are activated during perceptual decision making and confidence (R)
Jiwon Yeon, Medha Shekhar, Dobromir Rahnev
Age-related decrements in cortical gyrification: Evidence from an accelerated longitudinal dataset (R)
Christopher R Madan
A novel somatosensory spatial navigation system outside the hippocampal formation (R)
Xiaoyang Long, Sheng-Jia Zhang
Spontaneous emergence of behaviorally relevant motifs in human motor cortex
Tomer Livne, DoHyun Kim, Nicholas V Metcalf, Gordon L Shulman, Maurizio Corbetta
Functional genomic analyses highlights a shift in Gpr17-regulated cellular processes in oligodendrocyte progenitor cells (OPC) and underlying myelin dysregulation in the aged forebrain
Andrea D Rivera, Francesca Pieropan, Irene Chacon De La Rocha, Davide Lecca, Maria P Abbracchio, Kasum Azim, Arthur M Butt
Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories
Sarah Melzer, Elena Newmark, Grace Mizuno, Minsuk Hyun, Adrienne C Philson, Eleonora Quiroli, Beatrice Righetti, Malika Gregory, Kee Wui Huang, James Levasseur, Lin Tian, Bernardo Sabatini
The Big Five personality traits and CNS arousal in the resting state
Philippe Jawinski, Sebastian Markett, Christian Sander, Jue Huang, Christine Ulke, Ulrich Hegerl, Tilman Hensch
In Vivo two-photon imaging and parasympathetic neuromodulation of pancreatic microvascular dynamics in rats
Joseph S Canzano, Narayan Subramanian, Rebeca Castro, Abdurahman Siddiqi, Karim G Oweiss
Spontaneous alpha and theta oscillations are related to complementary aspects of cognitive control in younger and older adults (R)
Grace M Clements, Daniel C Bowie, Mate Gyurkovics, Kathy A Low, Monica Fabiani, Gabriele Gratton
TRPV1 feed-forward sensitisation depends on COX2 upregulation in primary sensory neurons (R)
Tianci Li, Gaoge Wang, Vivian Chin Chin Hui, Daniel Saad, Joao de Sousa Valente, Paolo La Montanara, Istvan Nagy
Abstract neural representations of category membership beyond information coding stimulus or response (R)
Robert M Mok, Bradley C Love
Time scale separation of information processing between sensory and associative regions (R)
Pierpaolo Sorrentino, Giovanni Rabuffo, Rosaria Rucco, Fabio Baselice, Emahnuel Troisi Lopez, Marianna Liparoti, Mario Quarantelli, Giuseppe Sorrentino, Christophe Bernard, Viktor Jirsa
Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain
Annika F Barber, Shi Yi Fong, Anna Kolesnik, Michael Fetchko, Amita Sehgal
Robust Cortical Criticality and Diverse Neural Network Dynamics Resulting from Functional Specification (R)
Lei Gu, Ruqian Wu
TrpML-mediated astrocyte microdomain Ca2+ transients regulate astrocyte-tracheal interactions in CNS (R)
Zhiguo Ma, Marc R. Freeman
Parallel organization of cerebellar pathways to sensorimotor, associative, and modulatory forebrain (R)
Thomas J Pisano, Zahra M Dhanerawala, Mikhail Kislin, Dariya Bakshinskaya, Esteban A Engel, Junuk Lee, Nina L de Oude, Kannan Umadevi Venkataraju, Jessica L Verpeut, Henk-Jan Boele, Samuel S.-H. Wang
Ultrastructural view of astrocyte-astrocyte and astrocyte-synapse contacts within the hippocampus
Conrad M Kiyoshi, Sydney Aten, Emily P Arzola, Jeremy A Patterson, Anne T Taylor, Yixing Du, Ally M Guiher, Merna Philip, Elizabeth Gerviacio Camacho, Devin Mediratta, Kelsey Collins, Emily Benson, Grahame Kidd, David Terman, Min Zhou
Dynamical consequences of regional heterogeneity in the brains transcriptional landscape
Gustavo Deco, Kevin M Aquino, Aurina Arnatkeviciute, Stuart Oldham, Kristina Sabaroedin, Nigel C Rogasch, Morten L. Kringelbach, Alex Fornito
Innervation and Neuronal Control of the Mammalian Sinoatrial Node: A Comprehensive Atlas
Peter Hanna, Michael J Dacey, Jaclyn Brennan, Alison Moss, Shaina Robbins, Sirisha Achanta, Natalia P Biscola, Mohammed Amer Swid, Pradeep Sundaram Rajendran, Shumpei Mori, Joseph Hadaya, Elizabeth H Smith, Stanley G Peirce, Jin Chen, Leif A Havton, Zixi (Jack) Cheng, Rajanikanth Vadigepalli, James Schwaber, Robert L Lux, Igor Efimov, John D Tompkins, Donald B Hoover, Jeffrey L Ardell, Kalyanam Shivkumar
Therapeutics
A novel equilibrative nucleoside transporter 1 inhibitor alleviates Tau-mediated neurodegeneration
Ching-Pang Chang, Ya-Gin Chang, Pei-Yun Chuang, Anh Thi Ngoc Nguyen, Fang-Yi Chou, Sin-Jhong Cheng, Hui-Mei Chen, Lee-Way Jin, Kevin Carvalho, Vincent Huin, Luc Buee, David Blum, Yung-Feng Liao, Chun-Jung Lin, Yijuang Chern
Working Memory and Impulsivity and Artificial Neural Networks
Robert Lodder, Markus Ville Tiitto
The Endothelin Receptor Antagonist Macitentan Ameliorates Endothelin-Mediated Vasoconstriction and Promotes Neuroprotection of Retinal Ganglion Cells in Rats
Dorota L Stankowska, Wei Zhang, Shaoqing He, Vignesh R Krishnamoorthy, Payton Harris, Trent Hall, Renuka M Chaphalkar, Bindu Kodati, Sai H Chavala, Raghu R Krishnamoorthy
Four Salvage NAD+ Biosynthetic Pathway Enzymes Moonlight as Molecular Chaperones to Protect Against Proteotoxicity
Meredith Pinkerton, Andrea Ruetenik, Victoriia Bazylianska, Eva Nyvltova, Antoni Barrientos
Oral administration of a dual ETA/ETB receptor antagonist promotes neuroprotection in a rodent model of glaucoma
Nolan R. McGrady, Dorota L. Stankowska, Hayden B. Jefferies, Raghu R. Krishnamoorthy
Anesthetic Drug Concentration Rather Than Abrupt Behavioral Unresponsiveness Linearly Degrades Responses in the Rat Primary Auditory Cortex
Lottem Bergman, Aaron J Krom, Yaniv Sela, Amit Marmelshtein, Hanna Hayat, Noa Regev, Yuval Nir
Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phophodiesterase 7 in the brain
Naoyuki Obokata, Chie Seki, Takeshi Hirata, Jun Maeda, Hideki Ishii, Yuji Nagai, Takehiko Matsumura, Misae Takakuwa, Hajime Fukuda, Takafumi Minamimoto, Kazunori Kawamura, Ming-Rong Zhang, Tatsuo Nakajima, Takeaki Saijo, Makoto Higuchi
A prospective longitudinal study shows putamen volume is associated with moderate amphetamine use and resultant cognitive impairments
Keith M Kendrick, Joerg Daumann, Daniel Wagner, Philip Koester, Marc Tittgemeyer, Qiang Luo, Euphrosyne Gouzoulis-Mayfrank, Benjamin Becker
(R) – Revision
Neuropreprints 