Image: Dopamine neuron synaptic connectivity defines physiological striatal domains (Nao Chuhma et al.)
Cellular
Multiple pathways of LRRK2-G2019S / Rab10 interaction in dopaminergic neurons (R)
Alison Fellgett, C. Adam Middleton, Jack Munns, Christopher Ugbode, David Jaciuch, Laurence Wilson, Sangeeta Chawla, Chris Elliott
Dopamine neuron synaptic connectivity defines physiological striatal domains
Nao Chuhma, Soo Jung Oh, Stephen Rayport
Voltage-gated Potassium Channels Control the Gain of Rod-driven light Responses in Mixed-input on Bipolar Cells
Christina Joselevitch, Jan Klooster, Maarten Kamermans
Emergence of irregular activity in networks of strongly coupled conductance-based neurons (R)
Alessandro Sanzeni, Mark H Histed, Nicolas Brunel
Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation
Clayton P Mosher, Adam N Mamelak, Mahsa Malekmohammadi, Nader Pouratian, Ueli Rutishauser
Malleability of the cortical hand map following a finger nerve block
Daan B Wesselink, Zeena-Britt Sanders, Laura R Edmondson, Harriet Dempsey-Jones, Paulina Kieliba, Sanne Kikkert, Andreas C Themistocleous, Uzay Emir, Joern Diedrichsen, Hannes P Saal, Tamar R Makin
Gene expression
The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction
Julie Secombe, Helen M Belalcazar, Emily L Hicks, Sumaira Zamurrad, Faith L.W. Liebl
The human brain vasculature shows a distinct expression pattern of SARS-CoV-2 entry factors
Moheb Ghobrial, Jason Charish, Shigeki Takada, Taufik Valiante, Philippe P. Monnier, Ivan Radovanovic, Gary D. Bader, Thomas Wälchli
Heterozygous deletion of SYNGAP enzymatic domains in rats causes selective learning, social and seizure phenotypes (R)
Danai Katsanevaki, Sally M Till, Ingrid Buller-Peralta, Thomas C Watson, Mohammad Sarfaraz Nawaz, Daisy Arkell, Shashank Tiwari, Vijay Kapgal, Syryanarayan Biswal, Joanna AB Smith, Natasha J Anstey, Lindsay Mizen, Nicholas Perentos, Matt W Jones, Mike A Cousin, Sumantra Chattarji, Alfredo Gonzalez-Sulser, Oliver Hardt, Emma R Wood, Peter C Kind
Functional spreading of hyperexcitability induced by human and synthetic intracellular Aβ oligomers
Eduardo J Fernandez-Perez, Braulio Munoz, Denisse A Bascunan, Christian Peters, Nicolas O Riffo-Lepe, Maria P Espinoza, Peter J Morgan, Caroline Filippi, Romain Bourboulou, Urmi Sengupta, Rakez Kayed, Jerome Epsztein, Luis G Aguayo
Subcellular sequencing of single neurons reveals the dendritic transcriptome of GABAergic interneurons
Erin M Schuman, Julio D Perez, Susanne tom Dieck, Beatriz Alvarez-Castelap, Ivy C.W. Chan
Molecular
Does dopamine synthesis capacity predict individual variation in curiosity?Lieke L. F. van Lieshout, Ruben van den Bosch, Lieke Hofmans, Floris P. de Lange, Roshan Cools
Beta2 oscillations in the hippocampal-cortical novelty detection circuit
Arthur S. C. Franca, Nils Borgegius, Bryan C Souza, Michael Cohen
Pathophysiology
Distinct Hierarchical Alterations of Intrinsic Neural Timescales Account for Different Manifestations of Psychosis
Kenneth Wengler, Andrew Goldberg, George Chahine, Guillermo Horga
A dominant-negative variant in the dopamine transporter PDZ-binding motif is linked to parkinsonism and neuropsychiatric disease
Freja Herborg, Kathrine Louise Jensen, Sasha Tolstoy, Natascha Voigt Arends, Leonie Pauline Posselt, Aparna Shekar, Jenny Aguilar, Viktor Karlovich Lund, Kevin Erreger, Mattias Rickhag, Matthew Domenic Lycas, Markus Nowak Lonsdale, Troels Rahbek-Clemmensen, Andreas Toft Sorensen, Amy H. Newman, Annemette Loekkegaard, Ole Kjaerulff, Thomas Werge, Lisbeth Birk Moeller, Heinrich JG Matthies, Aurelio Galli, Lena Elisabeth Hjermind, Ulrik Gether
Long-lasting tagging of neurons activated by seizures or cocaine administration in Egr1-CreERT2 transgenic mice
Sophie Longueville, Yuki Nakamura, Karen Brami-Cherrier, Renata Coura, Denis Herve, Jean-Antoine Girault
Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration
Jessika C Bridi, Erika Bereczki, Saffron K Smith, Goncalo M. Pocas, Benjamin Kottler, Pedro Domingos, Christopher J Elliott, Dag Aarsland, Frank Hirth
Imaging stable isotope labelling kinetics (iSILK) for following spatial Aβ plaque aggregation dynamics in evolving Alzheimers disease pathology
Wojciech Michno, Katie Mei Stringer, Thomas Enzlein, Melissa Passarelli, Stephane Escrig, Kaj Blennow, Henrik Zetterberg, Anders Meibom, Carsten Hopf, Frances A. Edwards, Jorg Hanrieder
Visual dysfunction predicts cognitive impairment and white matter degeneration in Parkinson’s disease
Angeliki Zarkali, Peter McColgan, Louise Ann Leyland, Andrew J Lees, Rimona S Weil
Inhibition of the phosphoinositide 3-kinase-AKT-cyclic GMP-c-Jun N-terminal kinase signaling pathway attenuates the development of morphine tolerance in a mouse model of neuropathic pain (R)
Travis Okerman, Taylor Jurgenson, Madelyn Moore, Amanda Helen Klein
Tau pathology spreads between anatomically-connected regions of the brain and is modulated by a LRRK2 mutation
Michael Henderson, Eli J Cornblath, Howard L Li, Lakshmi Changolkar, Bin Zhang, Hannah J Brown, Ronald J Gathagan, Modupe F Olufemi, Danielle S Bassett, John Q Trojanowski, Virginia M.Y. Lee
A molecular mechanism by which amyloid-β induces transcriptional inactivation of CREB in Alzheimer’s Disease
Katarzyna M. Grochowska, Rahul Kaushik, Guilherme M. Gomes, Rajeev Raman, Julia Baer, Gonca Bayraktar, Sebastian Samer, Irene Reyes-Resina, Christina Spilker, Marcel S. Woo, Arthur Bikbaev, Markus Morawski, Manuel A. Friese, Steffen Rossner, Gemma Navarro Brugal, Anna Karpova, Michael R. Kreutz
APP accumulates around dense-core amyloid plaques with presynaptic proteins in Alzheimer’s disease brain
Tomas Jorda-Siquier, Melina Petrel, Vladimir Kouskoff, Fabrice Cordelieres, Susanne Frykman, Ulrike Muller, Christophe Mulle, Gael Barthet
Structural and functional
Sex Differences in μ-opioid Regulation of Coerulear-Cortical Transmission
Herminio M Guajardo, Rita J Valentino
Scalable and accurate automated method for neuronal ensemble detection in spiking neural networks
Rubén Herzog, Arturo Morales, Soraya Mora, Joaquín Araya, María-José Escobar, Adrián G. Palacios, Rodrigo Cofré
Multiscale integration organizes hierarchical computation in human auditory cortex (R)
Sam V Norman-Haignere, Laura K Long, Orrin Devinsky, Werner Doyle, Ifeoma Irobunda, Edward Merricks, Neil A Feldstein, Guy M V McKhann, Catherine Schevon, Adeen Flinker, Nima Mesgarani
Complexity of intrinsic brain dynamics shaped by multiscale structural constraints (R)
Mengsen Zhang, Manish Saggar
Synapse-specific direction selectivity in retinal bipolar cell axon terminals
Akihiro Matsumoto, Weaam Agbariah, Stella Solveig Nolte, Rawan Andrawos, Hadara Levi, Shai Sabbah, Keisuke Yonehara
Sex-specific maturational trajectory of endocannabinoid plasticity in the rat prefrontal cortex
Axel Bernabeu, Anissa Bara, Antonia Manduca, Milene Borsoi, Olivier Lassalle, Anne-Laure Pelissier-Alicot, Olivier JJ Manzoni
BOLD response to multiple grip forces in MS: going beyond the main effect of movement in BA 4a and BA 4p
Adnan A.S. Alahmadi, Matteo Pardini, Rebecca S Samson, Egidio D’Angelo, Karl J Friston, Ahmed T Toosy, Claudia A.M. Gandini Wheeler-Kingshott
Functional Context Affects Scene Processing
Elissa M. Aminoff, Michael J. Tarr
Conduction velocity along the local axons of parvalbumin interneurons correlates with the degree of axonal myelination
Kristina D. Micheva, Marianna Kiraly, Marc M. Perez, Daniel V. Madison
Abstract neural representations of category membership beyond information coding stimulus or response (R)
Robert M. Mok, Bradley C. Love
AMP-activated protein kinase is a key regulator of acute neurovascular permeability (R)
Silvia Dragoni, Bruna Caridi, Eleni Karatsai, Thomas Burgoyne, Mosharraf H. Sarker, Patric Turowski
The claustrum-medial prefrontal cortex network controls attentional set-shifting
Leon Fodoulian, Olivier Gschwend, Chieko Huber, Sophie Mutel, Rodrigo Salazar, Roberta Leone, Jean-Rodolphe Renfer, Kazadi Ekundayo, Ivan Rodriguez, Alan Carleton
An interactive meta-analysis of MRI biomarkers of myelin
Matteo Mancini, Agah Karakuzu, Julien Cohen-Adad, Mara Cercignani, Thomas Nichols, Nikola Stikov
Differential impact of endogenous and exogenous attention on activity in human visual cortex (R)
Laura Dugue, Elisha P Merriam, David J Heeger, Marisa Carrasco
Selective connectivity limits functional binocularity in the retinogeniculate pathway of the mouse (R)
Joel Bauer, Simon Weiler, Martin Fernholz, David Laubender, Volker Scheuss, Mark Hübener, Tobias Bonhoeffer, Tobias Rose
Detection of the changes in dynamical structures in synchronous neural oscillations from a viewpoint of probabilistic inference (R)
Hiroshi Yokoyama, Keiichi Kitajo
Influence of sensory modality and control dynamics on human path integration
Akis Stavropoulos, Martin Fernholz, David Laubender, Volker Scheuss, Mark Hübener, Tobias Bonhoeffer, Tobias Rose
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol (R)
Hao Wang, Josh A. Kulas, Heather Ferris, Scott Hansen
Reducing SAR in 7T brain fMRI by circumventing fat suppression while removing the lipid signal through a parallel acquisition approach (R)
Amir Seginer, Edna Furman-Haran, Ilan Goldberg, Rita Schmidt
The effect of functionally-guided-connectivity-based rTMS on amygdala activation.
Lysianne Beynel, Ethan Campbell, Maria Naclerio, Jeffrey T Galla, Angikar Ghosal, Andrew M Michael, Nathan A Kimbrel, Simon W Davis, Lawrence G Appelbaum
Cross-modal orienting of exogenous attention results in visual-cortical facilitation, not suppression (R)
Jonathan M. Keefe, Emilia Pokta, Viola S. Stoermer
The Impact of Graph Construction Scheme and Community Detection Algorithm on the Reliability of Community and Hub Identification in Structural Brain Networks (R)
Stavros I Dimitriadis, Eirini Messaritaki, Derek K Jones
The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration
Amanda K Engstrom, Alicia C Walker, Rohitha A Moudgal, Dexter A Myrick, Stephanie M Kyle, Jordan Rowley, David J Katz
Brain preparedness: The proactive role of the cortisol awakening response
Bingsen Xiong, Changming Chen, Yanqiu Tian, Shouwen Zhang, Chao Liu, Tanya Evans, Guillen Fernandez, Jianhui Wu, Shaozheng Qin
The Orbitofrontal Cortex in Temporal Cognition
Juan Luis Romero Sosa, Dean Buonomano, Alicia Izquierdo
The effect of functionally-guided-connectivity-based rTMS on amygdala activation.
Lysianne Beynel, Ethan Campbell, Maria Naclerio, Jeffrey T Galla, Angikar Ghosal, Andrew M Michael, Nathan A Kimbrel, Simon W Davis, Lawrence G Appelbaum
Neural correlates of hand-object congruency effects during action planning
Zuo Zhang, Natalie Nelissen, Peter Zeidman, Nicola Filippini, Joern Diedrichsen, Karl Friston, Stefania Bracci, Elisabeth Rounis
Does somatosensory acuity influence the extent of internal model recalibration in young and older adults?
Koenraad Vandevoorde, Jean-Jacques Orban de Xivry
Spike-timing-dependent plasticity can account for aftereffects of dual-site transcranial alternating current stimulation
Bettina C. Schwab, Peter König, Andreas K. Engel
ɑ-Synuclein strains influence multiple system atrophy via central and peripheral mechanisms
Teresa Torre Murazabal, Anke Van der Perren, Audrey Coens, Anna Janer Barber, Sara Camacho-Garcia, Nadia Stefanova, Ronald Melki, Veerle Baekelandt, Wouter Peelaerts
The contribution of hippocampal subfields to the progression of neurodegeneration
Kichang Kwak, Marc Niethammer, Kelly S Giovanello, Martin Styner, Eran Dayan
Androgen regulation of bowel function in mice and humans
Daniella Rastelli, Ariel Robinson, Lynley T Matthews, Kristina Perez, William Dan, Peter Yim, Madison Mixer, Aleksandra Prochera, Rafla Hassan, Kathryn Hall, Sarah Ballou, Judy Nee, Anthony Lembo, Meenakshi Rao
Cortical synaptic diversity naturally arises with heterogeneous neural populations
Jacob L Yates, Benjamin Scholl
Distal CA1 maintains a more coherent spatial representation than proximal CA1 when local and global cues conflict
Sachin Suhas Deshmukh
Key Nucleation Stages and Associated Molecular Determinants and Processes in pH-Induced Formation of Amyloid Beta Oligomers as Revealed by High-Speed AFM
Lei Feng, Hiroki Watanabe, Paul Molino, Gordon Wallace, Son Lam Phung, Takayuki Uchihashi, Michael J Higgins
Therapeutics
Brain-Specific Inhibition of mTORC1 by a Dual Drug Strategy: A Novel Approach for the Treatment of Alcohol Use Disorder
Yann Ehinger, Ziyang Zhang, Khanhky Phamluong, Drishti Soneja, Kevan Shokat, Dorit Ron
(R) – Revision
Neuropreprints 