Image: Oral pyruvate prevents glaucomatous neurodegeneration
Pete A Williams et al.
Cellular
Distinct Microcircuit Response to Comparable Input from a Full and Partial Projection Neuron Population
Gabriel F. Colton, Aaron P. Cook, Michael P Nusbaum
Subthreshold repertoire and threshold dynamics of midbrain dopamine neuron firing in vivo (R)
Kanako Otomo, Jessica Perkins, Anand Kulkarni, Strahinja Stojanovic, Jochen Roeper, Carlos A Paladini
Obesity-induced astrocyte dysregulation of heterosynaptic plasticity within the orbitofrontal cortex
Benjamin K Lau, Ciaran Murphy-Royal, Manpreet Kaur, Min Qiao, Grant R Gordon, Jaideep S Bains, Stephanie L Borgland
Increased capillary stalling is associated with endothelial glycocalyx loss in subcortical vascular dementia (R)
Jin-Hui Yoon, Paul Shin, Jongyoon Joo, Gaon Sandy Kim, Wang-Yuhl Oh, Yong Jeong
α-Synuclein aggregation intermediates form fibril polymorphs with distinct prion-like properties (R)
Surabhi Mehra, Sahil Ahlawat, Harish Kumar, Nitu Singh, Ambuja Navalkar, Komal Patel, Pradeep Kadu, Rakesh Kumar, Narendra N Jha, Jayant B Udgaonkar, Vipin Agarwal, Samir K Maji
Impaired speed encoding is associated with reduced grid cell periodicity in a mouse model of tauopathy (R)
Thomas Ridler, Jonathan Witton, Keith G Phillips, Andrew D Randall, Jonathan T Brown
The Proline-rich Domain Promotes Tau Liquid Liquid Phase Separation in Cells
Xuemei Zhang, Michael Vigers, James McCarty, Jennifer N. Rauch, Glenn H. Fredrickson, Maxwell Z. Wilson, Joan-Emma Shea, Songi Han, Kenneth Kosik
Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons (R)
Bavat Bornstein, Idan Alyagor, Victoria Berkun, Hagar Meltzer, Fabienne Reh, Hadas Keren-Shaul, Eyal David, Thomas Riemensperger, Oren Schuldiner
Electron Microscopic Reconstruction of Neural Circuitry in the Cochlea (R)
Yunfeng Hua, Xu Ding, Haoyu Wang, Fangfang Wang, Yunge Gao, Yan Lu, Tobias Moser, Hao Wu
Energy supply per neuron is constrained by capillary density in the mouse brain (R)
Lissa Ventura-Antunes, Suzana Herculano-Houzel
Keratinocytes are required for normal cold and heat sensation
Katelyn E Sadler, Francie Moehring, Cheryl L Stucky
Dynamics and variability of neuronal subtype responses during regeneration and growth (R)
Jamie A Havrilak, Layla Al-Shaer, Noor Baban, Nesli Akinci, Michael J Layden
Macromolecular and electrical coupling between inner hair cells in the rodent cochlea
Philippe Jean, Tommi Anttonen, Susann Michanski, Antonio Miguel Garcia de Diego, Anna Maria Steyer, Andreas Neef, David Oestreicher, Jana Kroll, Christos Nardis, Tina Pangrsic, Wiebke Moebius, Jonathan Ashmore, Carolin Wichmann, Tobias Moser
Ascending dorsal column sensory neurons respond to spinal cord injury and downregulate genes related to lipid metabolism (R)
Eric E Ewan, Dan Carlin, Tassia Mangetti Goncalves, Guoyan Zhao, Valeria Cavalli
Gene expression
Snca-GFP knock-in mice reflect patterns of endogenous expression and pathological seeding
Anna Caputo, Yuling Liang, Tobias D Raabe, Angela Lo, Mian Horvath, Bin Zhang, Hannah J Brown, Anna Stieber, Kelvin Luk
Genetic Deletion of TrpV1 and TrpA1 Does not Alter Avoidance of or Patterns of Brainstem Activation to Citric Acid in Mice (R)
Tian Yu, Courtney E. Wilson, Jennifer M. Stratford, Thomas E. Finger
Acid sphingomyelinase inhibition results in profound rescue of neuronal function in glucocerebrosidase deficiency (G)
Marcus Keatinge, Matthew Gegg, Lisa Watson, Heather Mortiboys, Nan Li, Mark J Dunning, Deepak Ailani, Hai Bui, Astrid van Leens, Dirk Lefeber, Ryan MacDonald, Anthony Schapira, Oliver Bandmann
Molecular
Parkinson Disease-Linked Parkin Mediates Redox Reactions That Lower Oxidative Stress In Mammalian Brain (R)
Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Andy C. Ng, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi, Bojan Shutinoski, Juan Li, Angela P. Nguyen, Travis K. Fehr, Doo Soon Im, Steve Callaghan, David S. Park, Matthew J. LaVoie, Jennifer A Chan, Masashi Takanashi, Nobutaka Hattori, Rajiv R. Ratan, Luigi Zecca, Lawrence Puente, Gary S. Shaw, Mary-Ellen Harper, Arne Holmgren, Julianna J Tomlinson, Michael G. Schlossmacher
Central deficiency of norepinephrine synthesis and norepinephrinergic neurotransmission contributes to seizure-induced respiratory arrest (R)
Yue Shen, HaiXiang MA, Han Lu, HaiTing Zhao, Jianliang Sun, Yuan Cheng, Yi Shen, Yu Dong Zhou, HongHai Zhang
Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses (R)
Kirby M Donnelly, Olivia R DeLorenzo, Aprem D.A. Zaya, Gabrielle E Pisano, Wint M Thu, Liqun Luo, Ron R Kopito, Margaret M Panning Pearce
Platelet miRNA bio-signature discriminates between dementia with Lewy bodies and Alzheimer disease
Ana Gámez-Valero, Jaume Campdelacreu, Dolores Vilas, Lourdes Ispierto, Daniela Samaniego, Jordi Gascon-Bayarri, Ramón Reñé, Ramiro Alvarez, Maria P Armengol, Francesc E Borras, Katrin Beyer
Sleep is bi-directionally modified by amyloid beta oligomers (R)
Guliz Gurel Ozcan, Sumi Lim, Patricia L.A. Leighton, W Ted Allison, Jason Rihel
Cadherin-13 is a critical regulator of GABAergic modulation in human stem cell derived neuronal networks
Britt Mossink, Jon-Ruben van Rhijn, Shan Wang, Eline van Hugte, Katrin Linda, Jitske Bak, Anouk H Verboven, Martijn Selten, Alessia Anania, Sophie Jansen, Jason M Keller, Teun Klein Gunnewiek, Chantal Schoenmaker, Astrid Oudakker, Monica Frega, Hans van Bokhoven, Dirk Schubert, Nael Nadif Kasri
Different categories of fluorescent proteins result in GEVIs with similar characteristics
Jelena Platisa, Zhou Han, Vincent A Pieribone
The actin-modulating protein Synaptopodin mediates long-term survival of dendritic spines
Kenrick Yap, Alexander Drakew, Dinko Smilovic, Michael Rietsche, Mario Vuksic, Domenico Del Turco, Thomas Deller
Functional
Region-Specific PSD-95 Interactomes Contribute to Functional Diversity of Excitatory Synapses in Human Brain.
Adam Funk, Guillaume Labilloy, James Reigle, Rawan Alnafisah, Michael Heaven, Rosalinda Roberts, Behrouz Shamsaei, Kenneth Greis, Jarek Meller, Robert McCullumsmith
How tasks change whole-brain functional organization to reveal brain-phenotype relationships (R)
Abigail Sara Greene, Siyuan Gao, Stephanie Noble, Dustin Scheinost, Todd Constable
Using structural connectivity to augment community structure in EEG functional connectivity (R)
Katharina Glomb, Emeline Mullier, Margherita Carboni, Maria Rubega, Giannarita Iannotti, Sebastien Tourbier, Martin Seeber, Serge Vulliemoz, Patric Hagmann
Spatially resolved dendritic integration: Towards a functional classification of neurons (R)
Christoph Kirch, Leonardo L Gollo
Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis (R)
Stephanie Fore, Mehmet Ilyas Cosacak, Carmen Diaz Verdugo, Caghan Kizil, Emre Yaksi
Structural
Structural alterations in the macaque frontoparietal white matter network after recovery from prefrontal cortex lesions
Ramina Adam, David J Schaeffer, Kevin Johnston, Ravi S. Menon, Stefan Everling
Transient coupling between subplate and subgranular layers to L1 neurons before and during the critical period
Xiangying Meng, Yanqing Yu, Joseph Kao, Patrick O Kanold
A neural code for egocentric spatial maps in the human medial temporal lobe (R)
Lukas Kunz, Armin Brandt, Peter C. Reinacher, Bernhard P. Staresina, Eric T. Reifenstein, Christoph T. Weidemann, Nora A. Herweg, Melina Tsitsiklis, Richard Kempter, Michael J. Kahana, Andreas Schulze-Bonhage, Joshua Jacobs
Neuron Geometry Underlies Universal Network Features in Cortical Microcircuits
Eyal Gal, Rodrigo Perin, Henry Markram, Michael London, Idan Segev
Elucidating the complex organization of neural micro-domains in the locust Schistocerca gregaria using dMRI (R)
Syed Salman Shahid, Christian M. Kerskens, Malcolm Burrows, Alice G Witney
U-shape short-range extrinsic connectivity organisation around the human central sulcus
Alexandre Pron, Christine Deruelle, Olivier Coulon
Therapeutics
Compound 21, a two-edged sword with both DREADD-selective and off-target outcomes in rats.
Raphael Goutaudier, Veronique Coizet, Carole Carcenac, Sebastien Carnicella
Oral pyruvate prevents glaucomatous neurodegeneration
Pete A Williams, Jeffrey M Harder, Chelsea Guymer, John PM Wood, Evangelia Daskalakis, Glyn Chidlow, Brynn H Cardozo, Nicole E Foxworth, Kelly E Cochran, Tionna B Ouellette, Craig E Wheelock, Robert J Casson, Simon WM John
PI31 expression prevents neuronal degeneration in a mouse Parkinson Disease model
Hermann Steller, Adi Minis
Limited time window for retinal gene therapy in a preclinical model of ciliopathy
Poppy Datta, Avri Ruffcorn, Seongjin Seo
AAV9 gene therapy restores lifespan and treats pathological and behavioral abnormalities in a mouse model of CLN8-Batten disease
Tyler B Johnson, Katherine A White, Jacob T Cain, Logan Langin, Melissa A Pratt, Jon J Brudvig, Clarissa D Booth, Derek J Timm, Samantha S Davis, Brandon Meyerink, Shibi Likhite, Kathrin Meyer, Jill M Weimer
Nicotinamide mononucleotide treatment increases NAD+ levels in an iPSC Model of Parkinsons Disease
Brett Fulleylove-Krause, Samantha Sison, Allison Ebert
DMT alters cortical travelling waves
Andrea Alamia, Christopher Timmermann, Rufin VanRullen, Robin Carhart-Harris
Other
Criticality as a measure of developing proteinopathy in engineered human neural networks
Vibeke Devold Valderhaug, Kristine Heiney, Ola Huse Ramstad, Geir Braathen, Wei-Li Kuan, Stefano Nichele, Axel Sandvig, Ioanna Sandvig
Homeostatic mechanisms may shape the type and duration of oscillatory modulation. (R)
Erik J Peterson, Bradley Voytek
Heterosynaptic cross-talk of pre- and postsynaptic strengths along segments of dendrites
Rudi Tong, Nigel J Emptage, Yukiko Goda
(R) – Revision
Neuropreprints 