Molecular and Cellular Neuropreprints: W21, 2019

Divergent paths to seizure-like events
Neela K. Codadu, Robert Graham, Richard J. Burman, R. Thomas Jackson-Taylor, Joseph V. Raimondo, Andrew. J. Trevelyan, R. Ryley Parrish

Neural dynamics indicate parallel integration of environmental and self-motion information by place and grid cells
Dmitri Laptev, Neil Burgess

Unique axon-to-soma signaling pathways mediate dendritic spine loss and hyper-excitability post-axotomy
Tharkika Nagendran, Anne Marion Taylor

Huntington phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice
Yann Ehinger, Julie Bruyère, Nicolas Panayotis, Yah-Se Abada, Lydia Saidi, Valérie Matagne, ChiaraScaramuzzino, Hélène Vitet, Benoit Delatour, Laurent Villard, Frédéric Saudou, Jean-Christophe Roux

Neurophysiological alterations in the nucleus reuniens of a mouse model of Alzheimer’s disease
D.A. Walsh, J.T. Brown, A.D. Randall

Pericytes regulate vascular immune homeostasis in the CNS
Orsolya Török, Bettina Schreiner, Hsing-Chuan Tsai, Sebastian Utz, Johanna Schaffenrath, Sina Nassiri, Mauro Delorenzi, Adriano Aguzzi, May H. Han, Melanie Greter, Burkhard Becher, Annika Keller

Transplanted cells are essential for the induction but not the expression of cortical plasticity
Mahmood S. Hoseini, Benjamin Rakela, Quetzal Flores-Ramirez, Andrea R. Hasenstaub, Arturo Alvarez-Buylla, Michael P. Stryker

Parkin deficiency perturbs striatal circuit dynamics
Magdalena K. Baaske, Edgar R. Kramer, Durga Praveen Meka, Gerhard Engler, Andreas K. Engel, Christian K.E. Moll

Npas1+-Nkx2.1+ Neurons Form A Unique Pallidal Neuron Subclass
Zachary A. Abecassis, Brianna L. Berceau, Jeff P. Win, Daniela Garcia, Harry S. Xenias, Qiaoling Cui, Arin Pamucku, Vivian M. Hernández, Uree Chon, Byungkook Lim, Yongsoo Kim, Nicholas J. Justice, Raj Awatramani, C. Savio Chan

HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons
Niklas Byczkowicz, Abdelmoneim Eshra, Jacqueline Montanaro, Andrea Trevisiol, Johannes Hirrlinger, Maarten H. P. Kole, Ryuichi Shigemoto, Stefan Hallermann

Comparison of odor responses of homologous medial and lateral glomeruli mapped in the olfactory bulb of the mouse
Tokiharu Sato, Ryota Homma, Shin Nagayama

NEAT1 involves Alzheimer’s Disease (AD) progression via regulation of glycolysis and P-tau
Yiwan Zhao, Ziqiang Wang, Yunhao Mao, Bing Li, Yuanchang Zhu, Shikuan Zhang, Songmao Wang, YuyangJiang, Naihan Xu, Yizhen Xie, Weidong Xie, Yaou Zhang

NMDAR-activated PP1 dephosphorylates GluN2B to modulate NMDAR synaptic content.
Andrew M Chiu, Jiejie Wang, Michael P Fiske, Pavla Hubalkova, Levi Barse, John A Gray, Antonio Sanz-Clemente

TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Brain
Huynh TH Nguyen, Rhiannon J Wood, Alexa R Prawdiuk, Sebastian GB Furness, Junhua Xiao, SimonMurray, Jessica Fletche

A Subset of Olfactory Sensory Neurons Express Forkhead Box J1-Driven eGFP
Shivani Pathak, Eric D Larson, Vijay R Ramakrishnan, Tom E Finger

Ultrastructural heterogeneity of human layer 4 excitatory synaptic boutons in the adult temporal lobe neocortex
Rachida Yakoubi, Astrid Rollenhagen, Marec von Lehe, Dorothea Miller, Bernd Walkenfort, MikeHasenberg, Kurt Saetzler, Joachim Lübke

DYRK1A up-regulation specifically impairs a presynaptic form of long-term potentiation
Aude-Marie Lepagnol-Bestel, Simon Haziza, Julia Viard, Paul A Salin, Valerie Crepel, Arnaud Duchon, YannHerault, Michel Simonneau

Cross-species cortical alignment identifies different types of neuroanatomical reorganization in higher primates
Nicole Eichert, Emma C. Robinson, Katherine L. Bryant, Saad Jbabdi, Mark Jenkinson, Longchuan Li, Kristine Krug, Kate E. Watkins, Rogier B. Mars

Novel Strategies for Glutamate Clearance in the Glia-Deprived Synaptic Hub of C. elegans
Joyce Chan, Kirsten KyungHwa Lee, Jenny Chan Ying Wong, Paola Morocho, Itzhak Mano

Expression of c-Fos and Arc in hippocampal region CA1 marks neurons that exhibit learning-related activity changes
David Mahringer, Anders V. Petersen, Aris Fiser, Hiroyuki Okuno, Haruhiko Bito, Jean-François Perrier, Georg B. Keller

Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence
Alberto Granzotto, Manuela Bomba, Vanessa Castelli, Riccardo Navarra, Noemi Massetti, Marco Onofrj, Ilaria Cicalini, Piero del Boccio, Annamaria Cimini, Daniele Piomelli, Stefano L. Sensi

Loss of the Alzheimer’s-linked bridging integrator 1 (BIN1) protein affects synaptic structure and disrupts tau localisation and release
Elizabeth B. Glennon, Dawn H-W Lau, Rebecca M.C. Gabriele, Matthew F. Taylor, Claire Troakes, Christina Elliott, Richard Killick, Diane P. Hanger, Beatriz G. Perez-Nievas, Wendy Noble

Biological Aging in Childhood and Adolescence Following Experiences of Threat and Deprivation: A Systematic Review and Meta-Analysis
N.L. Colich, M.L. Rosen, E.S. Williams, K.A. McLaughlin

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions
Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian Spencer, Jiahui Tao, Michael F.Jobling, Shyra J. Gardai, Carlos W. Bertoncini, Nunilo Cremades, Michael Bova, Stephen Ballaron, Xiao-Hua Chen, Wenxian Mao, Phuong Nguyen, Mariano C. Tabios, Mitali A. Tambe, Jean-Christophe Rochet, Hans-Dieter Junker, Daniel Schwizer, Renate Sekul, Inge Ott, John P. Anderson, Balazs Szoke, WherlyHoffman, John Christodoulou, Ted Yednock, David A. Agard, Dale Schenk, Lisa McConlogue

Parkinson’s disease: a systemic inflammatory disease accompanied by bacterial inflammagens
Büin Adams, J Massimo Nunes, Martin J Page, Timothy Roberts, Jonathan Carr, Theo A Nell, Douglas BKell, Etheresia Pretorius

PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposits formation
Mercedes Arnes, Ninovska Romero, Sergio Casas-Tinto, Angel Acebes, Alberto Ferrus

Altered protein expression of galactose and N-acetylgalactosamine transferases in schizophrenia superior temporal gyrus
Toni M. Mueller, Nikita R. Mallepalli, James H. Meador-Woodruff

Constraints on Persistent Activity in a Biologically Detailed Network Model of the Prefrontal Cortex with Heterogeneities
Joachim Hass, Salva Ardid, Jason Sherfey, Nancy Kopell

Distinct properties of layer 3 pyramidal neurons from prefrontal and parietal areas of the monkey neocortex
Guillermo Gonzalez-Burgos, Takeaki Miyamae, Yosef Krimer, Yelena Gulchina, Diego Pafundo, OlgaKrimer, Holly Bazmi, Dominique Arion, John F Enwright, Kenneth Fish, David A Lewis

Neuronal TLR4 signaling enhances AMPA currents and drives posttraumatic epileptogenesis
Akshata Anand Korgaonkar, Ying Li, Dipika Shekhar, Deepak Subramanian, Jenieve Guevarra, BogumilaSwietek, Alexandra Pallottie, Sukwinder Singh, Kruthi Kella, Stella Elkabes, Vijayalakshmi Santhakumar

Progressive myoclonic epilepsy-associated gene Kctd7 regulates retinal neurovascular patterning and function
Jonathan Alevy, Courtney A. Burger, Nicholas E. Albrecht, Danye Jiang, Melanie A. Samuel

Neural trajectories in the supplementary motor area and primary motor cortex exhibit distinct geometries, compatible with different classes of computation
Abigail Russo, Ramin Khajeh, Sean R Bittner, Sean M Perkins, John P Cunningham, Laurence F Abbott, Mark M Churchland

Visual epidural field potentials possess high functional specificity in single trials
Benjamin Fischer, Andreas Schander, Andreas K. Kreiter, Walter Lang, Detlef Wegener

Exacerbation of blood brain barrier dysfunction and brain injury after aneurysmal subarachnoid hemorrhage in endothelial specific S1PR1 knock out mice
Akira Ito, Hiroki Uchida, Gab Seok Kim, Giuseppe Faraco, Richard Proia, Kuniyasu Niizuma, TeijiTominaga, Josef Anrather, Costantino Iadecola, Michael J Kluk, Teresa Sanchez

Selective modulation of the glucocorticoid receptor with CORT108297 during chronic adolescent stress evokes sex-specific effects in adulthood
Evelin Cotella, Rachel Morano, Aynara Wulsin, Susan Martelle, Paige Lemen, Maureen Fitzgerald, Benjamin A. Packard, Rachel Moloney, James Herman

Frontal eye field inactivation alters the readout of superior colliculus activity for saccade generation in a task-dependent manner
Tyler R. Peel, Suryadeep Dash, Stephen G. Lomber, Brian D. Corneil

Neuronal hyperexcitability drives TDP43 pathology by upregulating shortened TDP43 protein isoforms
Kaitlin Weskamp, Elizabeth M. Tank, Roberto Miguez, Nicolas B. Gomez, Matthew White, Zigiang Lin, Carmen Moreno Gonzalez, Andrea Serio, Jemeen Sreedharan, Sami J. Barmada

Fast signaling and focal connectivity of PV+ interneurons ensure efficient pattern separation by lateral inhibition in a full-scale dentate gyrus network model
Segundo Jose Guzman, Alois Schlögl, Claudia Espinoza, Xiaomin Zhang, Benjamin Suter, Peter Jonas

Dynamics of murine brain protein synthesis in vivo identify the hippocampus, cortex and cerebellum as highly active metabolic sites
Ser Sue Ng, Jung Eun Park, Wei Meng, Christopher Li-Hsian Chen, Raj N. Kalaria, Neil E. McCarthy, Siu Kwan Sze

Revisions

Insulin Producing Cells Monitor the Cold and Compensate the Cold-Induced Sleep inDrosophila
Xu O. Zhang, Xinyue Cui, Dikai Zhu

A non-spatial account of place and grid cells based on clustering models of concept learning
Robert M Mok, Bradley C Love

TRESK background K+ channel deletion selectively uncovers enhanced mechanical and cold sensitivity
Aida Castellanos, Anna Pujol-Coma, Alba Andres-Bilbe, Ahmed Negm, Gerard Callejo, David Soto, JacquesNoël, Nuria Comes, Xavier Gasull

Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS
Ernesto Manzo, Ileana Lorenzini, Dianne Barrameda, Abigail G. O’Conner, Jordan M. Barrows, AlexanderStarr, Tina Kovalik, Benjamin E. Rabichow, Erik M. Lehmkuhl, Dakotah D. Shreiner, Archi Joardar, Jean-Charles Liévens, Robert Bowser, Rita Sattler, Daniela C. Zarnescu

All-optical electrophysiology reveals excitation, inhibition, and neuromodulation in cortical layer 1
Linlin Z. Fan, Simon Kheifets, Urs L. Böhm, Kiryl D. Piatkevich, Hao Wu, Vicente Parot, Michael E. Xie, Edward S. Boyden, Anne E. Takesian, Adam E. Cohen

A comparative assessment of aging-related NADPH diaphorase positivity in the spinal cord and medullary oblongata between pigeon and murine
Yunge Jia, Wei Hou, Yinhua Li, Xiaoxin Wen, Chenxu Rao, Zichun Wei, Tianyi Zhang, Xinghang Wang, Xiuyuan Li, Lu Bai, Weijin Zhang, Pan Wang, Jing Bi, Anchen Guo, Jie Wang, Huibing Tan

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